Virginie Aris, Ph.D.

Bioinformatics Specialist
Center for Applied Genomics

Research Interests

My primary research interests are gene expression profiling in cancer and infectious diseases with a strong focus on biomarker discovery.  Additional interests include genotyping and personalized medicine. 

Education

Professional Experience

Professional Activities

Publications

  1. Fontán, P., Aris, V., Ghanny, S., Soteropoulos, P. and Smith, I. (2008) The global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection. Infect Immun. 76:717-25.
  2. Douard, V., Cui, X.-L., Soteropoulos, P. and Ferraris, R.P. (2008) Overcoming developmental limitations to intestinal sugar transport. Endocrinology 149:409-23.
  3. Tkachenko, O., Shepard, J., Aris, V., Joy, A., Bello, A., Londono, I., Marku, J., Soteropoulos, P. and Peteroy-Kelly, M.A. (2007) A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes. Research in Microbiology 158:651-8.
  4. Sampson, V.B., Rong, N.H., Han, J., Yang, Q.Y., Aris, V., Soteropoulos, P., Petrelli, N.J., Dunn, S.P. and Krueger, L.J. (2007) microRNA Let-7a Down Regulates the MYC Oncogene and Reverts MYC-induced Growth in Burkitt Lymphoma Cells. Cancer Research 67:9762-70.
  5. Kirchner, S., McDaniel, N.K., Sugiura, S.H., Soteropoulos, P., Tian, B., Fletcher, J.W. and Ferraris, R.P. (2007) Salmonid microarrays identify intestinal genes that reliably monitor P-deficiency in rainbow trout aquaculture. Animal Genetics 38:319-31.
  6. Wang, T., Zhang, X.A., Obijuru, L., Laser, J., Aris, V., Lee, P., Mittal, K., Soteropoulos, P. and Wei, J.J. (2007) MicroRNA Signature Associated with Race, Tumor Size and Target Gene Activity in Human Uterine Leiomyomas. Genes, Chromosomes and Cancer 46, 336-347
  7. Feinman, R., Deitch, E.A., Aris, V., Chu, H.B., Abungu, B., Caputo F.J., Galante, A., Xu, D., Lu, Q., Colorado, I., Streck, D., Dermody, J. and Soteropoulos, P. (2007) Molecular Signatures of Trauma Hemorrhagic Shock-Induced Lung Injury: Hemorrhage- and Injury-Associated Genes Shock. 28:360-368.
  8. Perkins, R.S., Sahm, K., Marando, C., Dickson-Witmer, D., Pahnke, G.R., Mitchell, M., Petrelli, N.J. Berkowitz, I.M., Soteropoulos, P., Aris, V.M., Dunn, S.P. and Krueger, L.J. (2006) Analysis of EBV Reservoirs in Paired Blood and Breast Cancer Primary Biopsy Specimens by Real-time PCR. Breast Cancer Res. 8, R70.
  9. Wang, Z., Aris, V.M., Ogburn, K.D. Soteropoulos, P and Figueiredo-Pereira, M.E. (2006) Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26s proteasome assembly in human neuroblastoma cells.  J. Biol Chem. 281, 21377-86
  10. Aris, V.M., Cody, M.J., Cheng, J., Dermody, J.J., Soteropoulos, P., Recce, M. and Tolias, P.P. (2004) Noise filtering and nonparametric analysis of microarray data underscores discriminating markers of oral, prostate, lung, ovarian and breast cancer. BMC Bioinformatics. 5, 185.
  11. Cui, X.-L. Soteropoulos, P., Tolias, P. and Ferraris, R.P (2004) Fructose-responsive genes in the small intestine of neonatal rats. Physiological Genomics 18,206-17.
  12. Ulger C., Toruner G.A., Alkan M., Mohammed M., Damani S., Kang J., Galante A., Aviv H., Soteropoulos P., Tolias P.P., Schwalb M.N. and Dermody J.J. (2003) Comprehensive genome-wide comparison of DNA and RNA level scans using microarray technology for identification of candidate cancer related genes in the HL60 cell line. Cancer Genetics and Cytogenetics 147, 28-35.
  13. Ramanathan, Y., Zhang, H., Aris, V., Soteropoulos, P., Aaronson, S.A., and Tolias, P.P. (2002) Functional Cloning, Sorting and Expression Profiling of Nucleic-Acid Binding Proteins.Genome Research 12, 1175-1189.
  14. Aris, V. and Recce, M (2002) A Method to Improve Detection of Disease Using Selectively Expressed Genes in Microarray Data. in Methods of Microarray Data Analysis, Papers from CAMDA '00. (eds. Lin, S. M. and Johnson, K. F.) Kluwer Academic Publishers, Boston, USA. 2002.

Presentations and Posters

  1. Gardiner, R.E. Ghanny, S., Aris, V. Park, S. Soteropoulos, P. and Perlin, D.S. (2006) Transcriptome analysis of Aspergillus fumigatus response to micafungin. 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA.
  2. Huang, Y., Zhang, Z., Aris, V., Ghanny, S., Soteropoulos, P., Rowe, J., Moffat, J. and Zhu, H. (2006) Using DNA microarray to study varicella zoster virus gene expression in t-cells in vivo. 31st Annual International Herpesvirus Workshop, Seattle, WA.
  3. Aris V, Streck, D, Toruner G, Soteropoulos, P and Dermody, J. 2005. Genotyping Chip: A spotted array-based open mutation testing system. 8th International Meeting of the Microarray Gene Expression Data Society, Sept. 11- 13, Bergen, Norway.
  4. Aris VM, D Streck, H Pedro, JJ Dermody, GA Toruner, 2005. Analysis of MDM2 SNP 309 polymorphism in breast cancer patients of Ashkenazi-Jewish descent. The 2005 Annual Retreat on Cancer Research in New Jersey, April 27, Princeton New Jersey.
  5. Aris VM, P Shu, TF Murphy, GA Toruner, HF Huang, AB Barton, BE Barton. 2005. Expression of constitutively-activated STAT3 in benign prostate cells changes the phenotype to one resembling neoplastic cells. The 2005 Annual Retreat on Cancer Research in New Jersey, April 27, Princeton New Jersey.
  6. Streck, D., Aris, V., Toruner, G.A., Soteropoulos, P. and Dermody, J.J. 2005. AJP: A microarray platform to test the Ashkenazi population for genetic Disease. Microarrays in Medicine, May 4-5, Boston, MA.
  7. Aris VM, J Hun , P Soteropoulos, M Recce, and PP Tolias, 2002. Application of the directional change assessment algorithm on microarray data to underscore markers that distinguish ovarian, breast and prostate cancer. Oncogenomics, May 1-5, Dublin, Ireland.
  8. Aris V, Tolias P, and Recce M, 2001. Selective Expression algorithm for class separation for DNA Microarrays. DIMACS Workshop on Analysis of Gene Expression Data, October 24 - 26, 2001, DIMACS Center, Rutgers University, Piscataway, NJ
  9. Aris, V. M., and Recce, M., 2000. A ranking method to improve detection of disease using selective expressed genes in Microarray data. CAMDA'00 Dec 18 and 19, Durham N.C.
  10. Aris, V. M., S. Leath, J. E. Bailey, and C. L. Campbell. 1999. Modeling the vertical Spread of Stagonospora nodorum Epidemics on Winter Wheat. Phytopathology, Vol. 86 No. 6 (Supplement) p. S3.
  11. Aris V. M., and J. E. Bailey, 1998. Adapting a Weather-Based Leafspot Advisory on Peanut to Partially resistant Genotypes. Poster session, APS meeting in Las Vegas. Phytopathology, Vol. 88 No. 9 (Supplement) p.S5.
  12. Aris, V. M., and J. E., Bailey, 1998. Adapting a Weather-Based Leafspot Advisory on Peanut to Partially resistant Genotypes. Presentation at the APRES meeting Norfolk Virginia. APRES Proceedings Vol. 30 p. 22.