Patricia Soteropoulos, Ph.D.

All Publications

  1. Bu, W., Palmeri, D., Krishnan, R., Marin, R., Aris, V.M., Soteropoulos, P. and Lukac, D.M. (2008) Identification of Direct Transcriptional Targets of the Kaposi’s sarcoma-associated herpesvirus Rta Lytic Switch Protein by conditional nuclear localization. Journal of Virology 82:10709-23.
  2. Fontán, P., Aris, V., Alvarez, M.E., Ghanny, S., Cheng, J., Soteropoulos, P., Trevani, A., Pine, R. and Smith, I. (2008) Mycobacterium tuberculosis Sigma Factor E Regulon Modulates the Host Inflammatory Response. Journal of Infectious Diseases 198:877-85.
  3. Wei, J.J. and Soteropoulos, P. (2008) MicroRNA: a new tool for biomedical risk assessment and target identification in human uterine leiomyomas. Semin. Reprod. Med. 26:515-21.
  4. Fontán, P., Aris, V., Ghanny, S., Soteropoulos, P. and Smith, I. (2008) The global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection. Infect Immun. 76:717-25.
  5. Douard, V., Cui, X.-L., Soteropoulos, P. and Ferraris, R.P. (2008) Overcoming developmental limitations to intestinal sugar transport. Endocrinology 149:409-23.
  6. Tkachenko, O., Shepard, J., Aris, V., Joy, A., Bello, A., Londono, I., Marku, J., Soteropoulos, P. and Peteroy-Kelly, M.A. (2007) A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes. Research in Microbiology 158:651-8.
  7. Sampson, V.B., Rong, N.H., Han, J., Yang, Q.Y., Aris, V., Soteropoulos, P., Petrelli, N.J., Dunn, S.P. and Krueger, L.J. (2007) microRNA Let-7a Down Regulates the MYC Oncogene and Reverts MYC-induced Growth in Burkitt Lymphoma Cells. Cancer Research 67:9762-70.
  8. Saaem, I., Papasotiropoulos, V., Wang, T., Soteropoulos, P. and Libera, M. (2007) Hydrogel-based protein nanoarrays. J. Nanosci. Nanotechnol. 7:2623-32.
  9. Akins, R.E., Gratton, K., Quezada, E., Rutter, H., Tsuda, T., and Soteropoulos, P. (2007) Gene Expression Profile of Bioreactor-Cultured Cardiac Cells: Activation of Morphogenetic Pathways for Tissue Engineering. DNA and Cell Biology 26:425-34.
  10. Kirchner, S., McDaniel, N.K., Sugiura, S.H., Soteropoulos, P., Tian, B., Fletcher, J.W. and Ferraris, R.P. (2007) Salmonid microarrays identify intestinal genes that reliably monitor P-deficiency in rainbow trout aquaculture. Animal Genetics 38:319-31.
  11. Merris, M., Wang, T., Soteropoulos, P. and Lenard, J. (2007) Differential gene expression of Caenorhabditis elegans on unmethylated and 4alpha -methyl sterols. J. Lipid Res. 48:1159-66.
  12. Pang, X., Vu, P., Byrd, T.F., Ghanny, S., Soteropoulos, P., Mukamolova, G.V., Wu, S., Samten, B. and Howard, S.T. (2007) Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology. 153:1229-42.
  13. Wang, T., Zhang, X.A., Obijuru, L., Laser, J., Aris, V., Lee, P., Mittal, K., Soteropoulos, P. and Wei, J.J. (2007) MicroRNA Signature Associated with Race, Tumor Size and Target Gene Activity in Human Uterine Leiomyomas. Genes, Chromosomes and Cancer 46, 336-347
  14. Feinman, R., Deitch, E.A., Aris, V., Chu, H.B., Abungu, B., Caputo F.J., Galante, A., Xu, D., Lu, Q., Colorado, I., Streck, D., Dermody, J. and Soteropoulos, P. (2007) Molecular Signatures of Trauma Hemorrhagic Shock-Induced Lung Injury: Hemorrhage- and Injury-Associated Genes Shock. 28:360-368.
  15. Liu, Y., Das, S., Olszewski, R.E., Carpenter, D.A., Culiat, C.T., Sundberg, J.P., Soteropoulos, P., Liu, X., Doktycz, M.J., Michaud, E.J. and Voy, B.H. (2007) The Near Naked Hairless (HrN) Mutation Disrupts Hair Formation but is not Due to a Mutation in the Hairless Coding Region. J. Invest. Derm.27:1605-14.
  16. Saaem I., Papasotiropoulos, V., Soteropoulos, P. and Libera, M. (2006) Arrayed Nanohydrogels for Protein Array Technology. Mater. Res. Soc. Symp. Proc. 897E:0897-J06-07.1.
  17. Perkins, R.S., Sahm, K., Marando, C., Dickson-Witmer, D., Pahnke, G.R., Mitchell, M., Petrelli, N.J. Berkowitz, I.M., Soteropoulos, P., Aris, V.M., Dunn, S.P. and Krueger, L.J. (2006) Analysis of EBV Reservoirs in Paired Blood and Breast Cancer Primary Biopsy Specimens by Real-time PCR. Breast Cancer Res. 8, R70.
  18. de la Fuente, C., Gupta, M.V., Klase, Z., Strouss, K., Cahan, P., McCaffery, T., Galante, A., Soteropoulos, P., Pumfery, A. Fujii, M. and Kashanchi, F. (2006)  Involvement of HTLV-I Tax and CREB in aneuploidy: A bioinformatics approach. Retrovirology. 3, 43
  19. Wang, Z., Aris, V.M., Ogburn, K.D. Soteropoulos, P and Figueiredo-Pereira, M.E. (2006) Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26s proteasome assembly in human neuroblastoma cells.  J. Biol Chem. 281, 21377-86
  20. Yang, S., Ghanny, S., Wang, W., Galante, A., Dunn, W., Liu, F., Soteropoulos, P., and Zhu, H. (2006) Using DNA Microarray to Study Human Cytomegalovirus Gene Expression. J. Virol. Methods. 131, 202-208
  21. Chang, T.N., Wang, T., Gandhi, K. and Soteropoulos, P. (2006) Automated Liquid Dispensing Pin for DNA Microarray Applications. IEEE TASE 3, 187-191
  22. Krsko, P., Saaem, I., Clancy, R., Geller, H., Soteropoulos, P. and Libera, M. (2005) E-Beam-Patterned Hydrogels to Control Nanoscale Surface Bioactivity. Proc. Of SPIE 6002, 600201- 1
  23. Gupta, V., Galante, A., Soteropoulos, P., Guo, S. and Wagner, B.J. (2005) Global Gene Profiling Reveals Novel Glucocorticoid Induced Changes in Gene Expression of Human Lens Epithelial Cells. Molecular Vision 11, 1018-40
  24. Duttagupta, R., Tian, B. Wilusz, C.J., Khounh, D.T., Soteropoulos, P., Ouyang, M., Dougherty, J.P. and Peltz, S.W. (2005) Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability. Mol. Cell. Biol. 13, 5499-513.
  25. Zhang, K., Ma, Q., Wang, H.-Y., Wang, Y., Wang, T., Yeh, I.-J., Jia, L., Shih, F. and Soteropoulos, P. (2005) Robust microarray image segmentation and quantification using extended local background. Proc. of the 6th International Conference on Computer Vision, Pattern Recognition and Image Processing, Salt Lake City, July 21-26, pp. 587- 590.
  26. Wang, T., Ma, Q. and Soteropoulos, P. (2005) Linking multiple genes to human chromosomal locations to facilitate knowledge discovery. Proc. of the 6th International Symposium on Computational Biology and Genome Informatics, Salt Lake City, July 21-26, pp. 1181-1184
  27. Gardiner, R.E., Soteropoulos, P., Park, S. and Perlin D.S. (2005) Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin. Medical Mycology Supplement 1, 43, S299-S305
  28. Netterwald, J., Yang, S., Wang, W., Ghanny, S., Cody, M., Soteropoulos, P., Tian, B., Dunn, W., Liu, F. and Zhu, H. (2005) Two GAS-like elements in the human cytomegalovirus major immediate-early promoter/enhancer are important for viral replication. J. Virol. 79, 5035-5046.
  29. Kimura, M., Cao, X., Skurnick, J., Cody, M., Soteropoulos, P. and Aviv, A. (2005) Proliferation Dynamics in Cultured Skin Fibroblasts from Down Syndrome Subjects. Free Radical Biology & Medicine 39, 374-380.
  30. Stein, T.P., Schluter, M.D., Galante, A.T., Soteropoulos, P., Ramirez, M., Bigbee, A., Grindeland, R.E and Wade, C.E. (2005) Effect of hind limb muscle unloading on liver metabolism of rats. J. Nutr. Biochem. 16, 9-16
  31. Aris, V.M., Cody, M.J., Cheng, J., Dermody, J.J., Soteropoulos, P., Recce, M. and Tolias, P.P. (2004) Noise filtering and nonparametric analysis of microarray data underscores discriminating markers of oral, prostate, lung, ovarian and breast cancer. BMC Bioinformatics. 5, 185.
  32. Price, R.M., Tulsyan, N., Dermody, J.J., Schwalb, M., Soteropoulos, P. and Castronuovo, J.J.  (2004) Gene expression after crush injury of human saphenous vein: Using microarrays to define the transcriptional profile.  J. Am. Coll. Surg. 199,211-8.
  33. Toruner, G.A., Ulger, C., Alkan, M., Galante, A.T., Rinaggio, J., Wilk, R., Tian, B., Soteropoulos, P., Hameed, M.R., Schwalb, M.N. and Dermody J.J. (2004) Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genetics and Cytogenetics 154, 27-35.
  34. Cui, X.-L. Soteropoulos, P., Tolias, P. and Ferraris, R.P (2004) Fructose-responsive genes in the small intestine of neonatal rats. Physiological Genomics 18,206-17.
  35. Hu, R., Hebbar, V., Kim, B-R., Chen, C., Winnik, B., Buckley, B., Soteropoulos, P., Tolias, P., Hart, R.P, and Kong, A-N.T. (2004) In vivo pharmacokinetics and pegulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther. 310, 263-71.
  36. Ulger C., Toruner G.A., Alkan M., Mohammed M., Damani S., Kang J., Galante A., Aviv H., Soteropoulos P., Tolias P.P., Schwalb M.N. and Dermody J.J. (2003) Comprehensive genome-wide comparison of DNA and RNA level scans using microarray technology for identification of candidate cancer related genes in the HL60 cell line. Cancer Genetics and Cytogenetics 147, 28-35.
  37. Qin, L., Qiu, P., Wang, L., Li, X., Swarthout, J.T., Soteropoulos, P., Tolias, P., and Partridge, N.C. (2003) Gene expression profiles and transcription factors involved in PTH signaling in osteoblasts revealed by microarray and bioinformatics. J. Biol. Chem. b, 19723-19731.
  38. Zhang, H., Ramanathan, Y., Soteropoulos, P., Recce, M., and Tolias, P.P. (2002) EZ-Retrieve: A web-server for batch retrieval of coordinate-specified human DNA sequences and underscoring putative transcription factor-binding sites. Nucleic Acids Research Vol. 30 No. 21 e121
  39. Ramanathan, Y., Zhang, H., Aris, V., Soteropoulos, P., Aaronson, S.A., and Tolias, P.P. (2002) Functional Cloning, Sorting and Expression Profiling of Nucleic-Acid Binding Proteins.Genome Research 12, 1175-1189.
  40. Stein, T. P., Schluter, M. D., Galante, A.T., Soteropoulos, P., Tolias, P.P., Grindeland, R.E., Moran, M., Wang, T.J., Polansky, M., and Wade, C.E. (2002) Energy Metabolism Pathways In Rat Muscle Under Conditions Of Simulated Microgravity Journal of Nutritional Biochemistry 13, 471-478.
  41. Nesic, O. Svrakic, N. Xu, G-Y., McAdoo, D., Westlund, K., Hulsebosch, C. Ziming, Y. Galante, A., Soteropoulos, P., Tolias, P., Young, W. Hart, R.P., and Perez-Polo, R. (2002) DNA microarray analysis of the contused spinal cord: The effect of NMDA receptor inhibition. Journal of Neuroscience Research 68, 406-423.
  42. Burghoorn, H.P., Soteropoulos, P., Paderu, P., Kashiwazaki, R., and Perlin, D.S. (2002) Molecular Evaluation of the Plasma Membrane Proton Pump from Aspergillus fumigatus. Antimicrob. Agents Chemother. 46, 615-624.
  43. Carmel, J.B., Galante, A., Soteropoulos, P., Tolias, P.P., Recce, M., Young, W. and Hart, R.P. (2001) Gene Expression Profiling of Acute Spinal Cord Injury Reveals Spreading Inflammatory Signaling and Evidence of Neuronal Loss.Physiological Genomics 7, 201-213.
  44. Soteropoulos, P., Valiakhmetov, A., Kashiwazaki, R. and Perlin, D.S. (2001) Helical stalk segments S4 and S5 of the plasma membrane H+-ATPase from Saccharomyces cerevisiae are optimized to impact catalytic site environment. J. Biol. Chem. 276, 16265-16270.
  45. Soteropoulos, P., Vaz, T., Santangelo, R., Paderu P., Huang, D.Y., Tamas, M., and Perlin, D.S. (2000) Molecular characterization of the plasma membrane H+-ATPase, an antifungal target in Cryptococcus neoformans. Antimicrob. Agents. Chemother. 44, 2349-2355.
  46. Hasper, A., Soteropoulos, P. and Perlin, D.S. (1999) Modification of the N-terminal polyserine cluster alters stability of the plasma membrane H+-ATPase from Saccharomyces cerevisiae. Biochim. Biophys. Acta, 1420, 214-222.
  47. Soteropoulos, P. and Perlin, D.S. (1998) Genetic probing of the stalk segments associated with M2 and M3 of the plasma membrane H+-ATPase from Saccharomyces cerevisiae. J. Biol. Chem. 273, 26426-26431
  48. Soteropoulos, P., Wang, G. and Perlin, D.S. (1998) Molecular genetic probing of energy coupling by the yeast plasma membrane proton pump. Acta Physiol. Scand. 163, Suppl. 643, 115-122
  49. Soteropoulos, P., Ong, A. M., and McCarty, R. E. (1994) Alkylation of Cys-89 of the g subunit of the chloroplast ATP synthase alters nucleotide interactions. J. Biol. Chem. 269, 19810-19816.
  50. Soteropoulos, P., Süss, K.-H., and McCarty, R. E. (1992) Modifications of the g subunit of chloroplast coupling factor 1 alter interactions with the inhibitory e subunit. J. Biol. Chem. 267, 10348-10354.
  51. Jacobson, B. M., Soteropoulos, P., and Bahadori, S. (1988) Aromatization of 1,4-cyclohexadienes with tetracyanoethylene: A case of varying mechanisms. J. Org. Chem. 53, 3247-3255.