Patricia Soteropoulos, Ph.D.

Director
Center for Applied Genomics

Research Interests

Microarray technology provides researchers with the ability to easily study tens of thousands of genes or gene products simultaneously. Microarrays have become a standard laboratory tool and have found a role in both basic and applied biological research including the elucidation of pathways and networks, biomarker selection, drug discovery and the development of diagnostic and prognostic tests.

My research program centers on the application and development of microarray methods and technology. The research interests of my laboratory include expression profiling in cancer and infectious diseases and the development of novel DNA nanoarrays , self-reporting microarrays and microfluidic arrays.

 

Recent Publications

  1. Fontán, P., Aris, V., Ghanny, S., Soteropoulos, P. and Smith, I. (2008) The global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection. Infect Immun. 76:717-25.
  2. Douard, V., Cui, X.-L., Soteropoulos, P. and Ferraris, R.P. (2008) Overcoming developmental limitations to intestinal sugar transport. Endocrinology 149:409-23.
  3. Tkachenko, O., Shepard, J., Aris, V., Joy, A., Bello, A., Londono, I., Marku, J., Soteropoulos, P. and Peteroy-Kelly, M.A. (2007) A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes. Research in Microbiology 158:651-8.
  4. Sampson, V.B., Rong, N.H., Han, J., Yang, Q.Y., Aris, V., Soteropoulos, P., Petrelli, N.J., Dunn, S.P. and Krueger, L.J. (2007) microRNA Let-7a Down Regulates the MYC Oncogene and Reverts MYC-induced Growth in Burkitt Lymphoma Cells. Cancer Research 67:9762-70.
  5. Saaem, I., Papasotiropoulos, V., Wang, T., Soteropoulos, P. and Libera, M. (2007) Hydrogel-based protein nanoarrays. J. Nanosci. Nanotechnol. 7:2623-32.
  6. Akins, R.E., Gratton, K., Quezada, E., Rutter, H., Tsuda, T., and Soteropoulos, P. (2007) Gene Expression Profile of Bioreactor-Cultured Cardiac Cells: Activation of Morphogenetic Pathways for Tissue Engineering. DNA and Cell Biology 26:425-34.
  7. Kirchner, S., McDaniel, N.K., Sugiura, S.H., Soteropoulos, P., Tian, B., Fletcher, J.W. and Ferraris, R.P. (2007) Salmonid microarrays identify intestinal genes that reliably monitor P-deficiency in rainbow trout aquaculture. Animal Genetics 38:319-31.
  8. Merris, M., Wang, T., Soteropoulos, P. and Lenard, J. (2007) Differential gene expression of Caenorhabditis elegans on unmethylated and 4alpha -methyl sterols. J. Lipid Res. 48:1159-66.
  9. Pang, X., Vu, P., Byrd, T.F., Ghanny, S., Soteropoulos, P., Mukamolova, G.V., Wu, S., Samten, B. and Howard, S.T. (2007) Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology. 153:1229-42.
  10. Wang, T., Zhang, X.A., Obijuru, L., Laser, J., Aris, V., Lee, P., Mittal, K., Soteropoulos, P. and Wei, J.J. (2007) MicroRNA Signature Associated with Race, Tumor Size and Target Gene Activity in Human Uterine Leiomyomas. Genes, Chromosomes and Cancer 46, 336-347

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